Two sample MR report
HLA-DQA1_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 35 | 0.2034027 | 0.1248009 | 0.1126499 |
| Weighted median | 35 | -0.0960060 | 0.0170272 | 0.0000000 |
| Inverse variance weighted | 35 | -0.0890397 | 0.0129615 | 0.0000000 |
| Simple mode | 35 | -0.1473180 | 0.0334539 | 0.0001004 |
| Weighted mode | 35 | -0.1387536 | 0.0358147 | 0.0004637 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 33.31722 | 33 | 0.4518319 |
| Inverse variance weighted | 38.91418 | 34 | 0.2580233 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.160846 | 0.0683143 | 0.0246495 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005094 | 1e-07 | TRUE | 0.0333396 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
